Alice Mui, BSc PhD

Associate Professor
Director of Master of Science in Surgery

Research- Jack Bell Research Centre / VGH
Co-Director of Centre for Surgical Research, Department of Surgery

Associate Member, Department of Biochemistry and Molecular Biology

City: Vancouver
Hospital Authority: Vancouver Coastal Health

Address: Jack Bell Research Centre
2660 Oak Street Vancouver, BC V6H 3Z6

Phone Lab: 604.875.4111 extension 62242     Fax: 604.875.4497

Email: alice.mui@ubc.ca

Special Interest

  • Immunology research
  • Graduate and Undergraduate teaching

Research Interest: Inflammatory Signalling Pathways

Dr. Mui’s laboratory studies the mechanism by which negative regulators like IL10 inhibit target cells in order to intervene therapeutically during deregulated immune responses. Her group has identified an agonist of the inositol phosphatase SHIP, which mimics the anti-inflammatory action of IL10. Her laboratory confirmed that the agonist inhibits inflammation in animal models of septicemia and colitis – both diseases resulting from over-enthusiastic activation of the immune system. The agonist has now been licensed to a spin-off company for clinical development for the treatment of human inflammatory disease. The Mui lab is now characterizing small molecule SHIP inhibitors which might be used to reverse pathogen-induced immunosuppression. Work is also continuing towards characterizing other signalling pathways utilized by IL10 and other negative immune cell regulators.

Publications PubMed publication listing.