Lucy Marzban, DMLS PhD
Rm 288 – VGH Research Pavilion – 828 West 10th Avenue | Vancouver, BC, V5Z 1M9
Phone: 604.875.4111 extension 61742
Type 1 diabetes and islet transplantation: Identifying the cell death signalling pathways by which non-immune factors such as islet amyloid formation mediate beta-cell death in human islets during pre-transplant culture and following transplantation. Through these studies we hope to find new approaches to enhance survival and function of islet grafts in type 1 diabetic recipients.Type 2 diabetes and beta-cell apoptosis: Identifying the molecular mechanisms by which islet amyloid formation mediates beta-cell death in type 2 diabetes and finding new ways to prevent amyloid toxicity.Role of islet alpha cells in diabetes: Investigating the underlying molecular mechanisms that contribute to the better survival of islet alpha-cells in conditions associated with beta-cell death such as type 2 diabetes, islet culture, and transplantation.
1] Park YJ, Ao Z, Kieffer TJ, Chen H, Safikhan N, Thompson DM, Meloche M, Warnock GL, Marzban L: The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: Implications in type 2 Diabetes and islet transplantation. Diabetologia 56(3): 508-519, 2013.
2] Park YJ, Lee S, Kieffer TJ, Warnock GL, Safikhan N, Speck M, Hao Z, Woo M, Marzban L: Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia 55(4): 1035-1047, 2012.
3] Park YJ, Zhang Y, Ao Z, Meloche M, Warnock GL, Marzban L: The IL-1 receptor antagonist Anakinra enhances survival and function of human islets during culture: Implications in clinical islet transplantation. Can J Diabetes 36: 244-250, 2012.
4] Zhang Y, Jalili RB, Warnock GL, Ao Z, Marzban L, Ghahary A. Three-dimensional scaffolds reduce islet amyloid formation and enhance survival and function of cultured human islets. Am J Pathol 181(4):1296-1305, 2012.
5] Law E, Lu S, Kieffer TG, Warnock GL, Ao Z, Marzban L: Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3. Diabetologia 53(7):1415-1427, 2010.
6] Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB: siRNA-Mediated Suppression of Pro-Islet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 57(11):3045-3055, 2008.
7] Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, and Verchere CB: Impaired NH2-terminal processing of human pro-islet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes 55: 2192-2201, 2006.