Brad G. Hoffman, BSc PhD
Active Staff – Scientist Level 1, CFRI
BC Children’s Hospital Research Institute
A4-185, 950 West 28th Avenue
Vancouver, BC V5Z 4H4
Phone: 604.875.2000 extension 4794 Fax: 604.875.2373
FOCUS : Understanding how the genes critical to endocrine pancreas development, as well as β-cell function and proliferation are regulated is essential for the development of novel strategies for the production of insulin-secreting cells, and for improving the efficacy of available transplantable material. The recent development of several novel experimental techniques is beginning to make the elucidation of the mechanisms behind the control of β-cell critical genes, on a global basis, a feasible and tractable task in mammalian biology. The utilization of these techniques to understand endocrine pancreas development and function is highly novel and potentially extremely significant in advancing our understanding of these processes and is the focus of our research.
Detailed information about scholarly, professional activities
Campbell S, Hoffman BG. (2016) Chromatin regulators in pancreas development and diabetes. Trends in Endocrinology and Metabolism. 27, 142–152.
Tennant B, Vanderkruk B, Dhillon J, Dai D, Verchere B, Hoffman BG. (2016) Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction. Cell Death and Disease. 7, e2233
Tennant B, Chen J, Shih A, Luciani D, Hoffman BG. (2015) Myt3 mediates laminin-V/integrin-β1 induced islet-cell migration via Tgfbi. Molecular Endocrinology. Sep;29(9):1254-68.
Tennant B, Hurley P, Gill A, Whiting C, Hoffman BG. (2015) The TrxG complex mediates cytokine induced de novo enhancer formation in islets. PLOS ONE 10, e0141470.
Tennant B, Robertson A.G, Kramer M, Li L, Zhang X, Beach M, Thiessen N, Chiu R, Mungall K, Whiting C, Sabatini PV, Kim A, Gottardo R, Marra M, Lynn FC, Jones SJM, Hoodless PA, Hoffman BG. (2012) Identification and analysis of pancreatic islet enhancers. Diabetologia. 56(3): 542-552.
Tennant B, Islam R, Kramer M, Merkulova Y, Kiang R, Whiting C, Hoffman BG. (2012) The transcription factor Myt3 acts as a pro-survival factor in β-cells. PLoS One. 7(12):e51501. doi: 10.1371/journal.pone.0051501.
Mehran AE, Templeman N, Brigidi GS, Lim GE, Chu KY, Botezelli JD, Hu X, Asadi A, Hoffman BG, Kieffer TJ, Bamji SX, Clee SM, Johnson JD. (2012) Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. Cell Metabolism. 16(6): 723-737.
Szabat M, Lynn F, Hoffman BG, Kieffer TJ, Allan DW, Johnson JD. (2012). Maintenance of β-cell maturity and plasticity in the adult pancreas: Developmental biology meets physiology. Diabetes. Jun;61(6):1365-71.
Hoffman BG, Robertson G, Zavaglia B, Beach M, Cullum R, Lee S, Soukhatcheva G, Li L, Wederell ED, Thiessen N, Bilenky M, Cezard T, Tam A, Kamoh B, Birol I, Dai D, Zhao Y, Hirst M, Verchere B, Helgason CD, Marra MA, Jones SJM, Hoodless PA. (2010). Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver. Genome Research; 20(8): 1037-1051.
Hoffman BG, Jones S. (2009). Genome-wide identification of DNA–protein interactions using chromatin immunoprecipitation coupled with flow cell sequencing. Journal of Endocrinology. 201, 1–13.
Hoffman BG, Zavaglia B, Witzsche J, Beach M, & Helgason CD. (2008). Expression of the Groucho/Tle proteins during pancreas development. BMC Dev. Biol; Sep 8, 8:81, 2008.
Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Thiessen N, Bilenky M, Hoodless PA, Jones S, Marra M, & Helgason CD. (2008). Identification of Transcripts with Enriched Expression in the Developing and Adult Pancreas. Genome Biology; 9(6): R99.
Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman BG, Holt R, Hou J, Kuo B Y-L, Lee Lisa LC, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A-L, Pandoh P, Riggins GJ, Ruiz de Algara T, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie Yuan-Yun, Yang G, Zhang I, Hirst M, Jones SJM, Helgason CD, Simpson EM, Hoodless PA, Marra Marco. (2005). A mouse atlas of Gene Expression: A public, large-scale, digital gene expression profiling resource from precisely defined developing C57BL/6J mouse tissues and cells. PNAS. 102(51): 18485-18490.This paper was listed as one of the “top 20” most viewed papers in PNAS.